{"id":20,"date":"2018-01-03T17:13:25","date_gmt":"2018-01-03T17:13:25","guid":{"rendered":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/?page_id=20"},"modified":"2018-04-23T11:25:05","modified_gmt":"2018-04-23T11:25:05","slug":"syllabus-gn434-2018","status":"publish","type":"page","link":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/syllabus-gn434-2018\/","title":{"rendered":"Syllabus"},"content":{"rendered":"

Textbook: Developmental Biology <\/em>by Scott Gilbert – 11th edition<\/strong><\/h3>\n
\n

Instructor Dr. Robert Franks; Room 2548, Thomas Hall<\/p>\n

Email: rgfranks (at) ncsu.edu Phone: 513-7705<\/p>\n

Office hours: by appointment<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

January \u00a0 8<\/p>\n<\/td>\n

\n

Introduction to Developmental Biology –\u00a001_08_18<\/a><\/p>\n<\/td>\n

\n

Read Chapter 1 – hand in answer to one of these two questions – due Jan 10th\u00a0\u00a0first_day_discussion_questions.docx<\/a><\/p>\n<\/td>\n<\/tr>\n

\n

January \u00a0 10<\/p>\n<\/td>\n

\n

In Class discussion of overview questions – 01_10_18<\/a><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

January 12<\/p>\n<\/td>\n

\n

Developmental Anatomy, Fate mapping, Cell Lineage, medical embryology – 01_12_18v1<\/a><\/p>\n<\/td>\n

\n

Chapter 1<\/p>\n<\/td>\n<\/tr>\n

\n

January 15<\/p>\n<\/td>\n

\n

MLK Holiday – no class<\/p>\n

Prep three questions or comments to hand in on Jan 17th related to Barresi Lab dev bio tutorial – USE MOODLE<\/a><\/strong><\/p>\n<\/td>\n

\n

Prep for chapter 3 – Watch dev tutorial<\/strong><\/p>\n

https:\/\/sophia.smith.edu\/blog\/barresilab\/devidetorials\/#differential-gene-expression<\/a><\/strong><\/td>\n<\/tr>\n

\n

Jan 17th<\/p>\n<\/td>\n

\n

SNOW DAY!!<\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

January 19<\/p>\n<\/td>\n

\n

Discussion of Barresi Lab Dev Bio tutorial – 01_17_18v1<\/a><\/p>\n<\/td>\n

\n

Chapter 3<\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

January 22<\/p>\n<\/td>\n

\n

Differential gene expression, parts of a gene, transcriptional regulation<\/p>\n

\n<\/td>\n

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Chapter 3<\/p>\n<\/td>\n<\/tr>\n

\n

January 24<\/p>\n<\/td>\n

\n

Differential gene expression, genetic screens, types of evidence<\/p>\n

01_24and26__18v3<\/a><\/p>\n<\/td>\n

\n

Chapter 3<\/p>\n

a good wikipedia page<\/a> on histones covering additional details just FYI<\/p>\n<\/td>\n<\/tr>\n

\u00a0\u00a0January 26<\/td>\n\n

Differential gene expression, genetic screens, types of evidence<\/p>\n<\/td>\n

\u00a0first monkeys cloned – news release<\/a> this week<\/td>\n<\/tr>\n
<\/td>\nPrep for chapter 4 – watch dev tutorial
\nPrep three questions or comments to hand in on Jan 29th related to Barresi Lab dev bio tutorial USE MOODLE SITE<\/a><\/strong><\/td>\n		\u00a0watch dev tutorial on morphogen signaling<\/p>\n

–\u00a0https:\/\/sophia.smith.edu\/blog\/barresilab\/devidetorials\/#morphogen-signaling<\/a><\/td>\n<\/tr>\n

\u00a0January 29<\/td>\nDifferential gene expression –\u00a0 last lecture<\/td>\nChapter\u00a03<\/td>\n<\/tr>\n
\n

Jan 31<\/p>\n<\/td>\n

Cell Signaling Paracrine factors 01_31_18<\/a><\/td>\n\n

Chapter 4<\/p>\n<\/td>\n<\/tr>\n

\n

Feb.\u00a02<\/p>\n<\/td>\n

\n

Extracellular matrix –\u00a0induction – competence –02_02_18v3<\/a><\/p>\n<\/td>\n

\n

Chapter 4<\/p>\n<\/td>\n<\/tr>\n

\n

Feb.\u00a05<\/strong><\/p>\n<\/td>\n

\n

EXAM I<\/strong><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

Feb 7.<\/p>\n<\/td>\n

\n

Plants and meristems 02_07_GN434_2018plantsv2<\/a><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

Feb.\u00a09<\/p>\n<\/td>\n

\n

Dr. Tim Kelliher, Syngenta Crop Protection – DEVBIOL_KELLIHER<\/a><\/p>\n<\/td>\n

\u00a0Haploid induction: Plants, Development and Biotechnology<\/td>\n<\/tr>\n
\n

Note:<\/p>\n<\/td>\n

Choose\u00a0paper to present in group presentation by Feb 16th<\/td>\n\u00a0email me you favorite two topics\/papers from list of topics<\/td>\n<\/tr>\n
<\/td>\n\n

Watch drosophila introduction video\u00a0\u00a0\u00a0\u00a0 click here for video – <\/a>Prepare 3 questions or comments regarding this video to be turned in Feb. 12th.<\/p>\n<\/td>\n

\u00a0short bonus video<\/a> on forward and reverse genetics in drosophlia<\/td>\n<\/tr>\n
\n

Feb. 12<\/p>\n<\/td>\n

Drosophila part I – 02_12_18drosophila_I<\/a><\/td>\n\n

Ch<\/span> 9\u00a0\u00a0first half – a rather basic video<\/a> on recombination mapping but good for review if you have forgotten<\/p>\n<\/td>\n<\/tr>\n

\n

Feb. 14<\/p>\n<\/td>\n

\u00a0Drosophila<\/td>\n\n

Ch<\/span> 9<\/p>\n<\/td>\n<\/tr>\n

\n

Feb. 16<\/p>\n<\/td>\n

Drosophila<\/td>\n\n

Ch<\/span> 9<\/p>\n<\/td>\n<\/tr>\n

\n

Feb.\u00a019<\/p>\n<\/td>\n

drosophila – discussion of original researcher paper\u00a0–\u00a0powerpoints from paper<\/a><\/td>\nStathopoulous et al 2002 –\u00a0click here for drosophila dorsal ventral paper<\/a><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

Feb 21<\/p>\n<\/td>\n

Drosophila part IIa<\/p>\n

02_14_18drosophila_II<\/a><\/td>\n

\n

Ch<\/span> 9\u00a0second half<\/p>\n<\/td>\n<\/tr>\n

\n

Feb 23<\/p>\n<\/td>\n

\n

\u00a0Drosophila part III –\u00a002_23_18 drosophilaIII<\/a><\/p>\n<\/td>\n

\u00a0Ch<\/span> 9\u00a0second half<\/td>\n<\/tr>\n
<\/td>\n\u00a0prep for stem cell chapter watch dev bio tutorial – Prep three questions to hand in on Feb 26<\/td>\n\u00a0dev bio tutorial –\u00a0https:\/\/sophia.smith.edu\/blog\/barresilab\/devidetorials\/#stem-cell-basic<\/a><\/strong>s<\/td>\n<\/tr>\n
\n

Feb 26<\/p>\n<\/td>\n

\n

Mammalian homeotic and Stem Cells –\u00a002_28_18 homeoticmouseandstemcells<\/a><\/p>\n<\/td>\n

\n

Chapter 5<\/p>\n<\/td>\n<\/tr>\n

\n

Feb 28<\/p>\n<\/td>\n

\n

Stem Cells<\/p>\n<\/td>\n

\n

Chapter 5<\/p>\n<\/td>\n<\/tr>\n

\n

March\u00a02<\/strong><\/p>\n<\/td>\n

EXAM II\u00a0 \u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/a><\/strong><\/td>\n\u00a0Link on Hox gene colinearity<\/a> – why are hox genes organized on the chromosome as they are organized on the anterior posterior axis of the embryo?<\/td>\n<\/tr>\n
\n

March\u00a05-9 spring break<\/strong><\/p>\n<\/td>\n

\n

SPRING BREAK – NO CLASSES<\/strong><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

March 12<\/p>\n<\/td>\n

stem cells and ips cells\u00a002_28_18_homeoticmouseandstemcellsv3<\/a><\/td>\nChapter 5<\/td>\n<\/tr>\n
\n

March14<\/p>\n<\/td>\n

Amphibian Axis I powerpoint slides\u00a003_14_18_amphibiansI<\/a><\/td>\n\n

Chapter 11 – up to p. 365<\/p>\n

\n<\/td>\n<\/tr>\n

<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

March\u00a0\u00a0\u00a0\u00a0 16<\/p>\n<\/td>\n

Discuss: Induction of Pluripotent Stem Cells \u2013 link to .ppt of
\nslides\u00a0\u00a003_16_18_iPSymanakapaperv3<\/a><\/td>\n		read Yamanaka research paper –\u00a0click here to read iPS cells yamanaka and takahashi paper<\/a><\/p>\n

\n<\/td>\n<\/tr>\n

\n

March\u00a0\u00a0\u00a0\u00a0 19<\/p>\n<\/td>\n

\n

Amphibian Axis II –\u00a003_19_18amphibianspartsIIandIIIv3<\/a><\/p>\n<\/td>\n

Chapter 11 up to p365<\/td>\n<\/tr>\n
\n

March \u00a0 \u00a021<\/p>\n<\/td>\n

\n

Amphibians finish up<\/p>\n<\/td>\n

\n

\n<\/td>\n<\/tr>\n

\n

March \u00a0 \u00a023<\/strong><\/p>\n<\/td>\n

\n

Guest Lecture \u00a0– C. Elegans – Jim Mahaffey –\u00a0Cell Death 2018<\/a><\/p>\n<\/td>\n

INTRO to C. elegans video<\/a> – please watch before today’s class<\/td>\n<\/tr>\n
March \u00a0 \u00a026<\/td>\n\n

Neural Crest development\u00a0CH15_neural crest<\/a><\/p>\n<\/td>\n

Chapter 15 pp. 463-488<\/td>\n<\/tr>\n
\n

March 28<\/p>\n<\/td>\n

\n

Zebrafish neural crest and cancer – read and discuss the research paper<\/p>\n<\/td>\n

\u00a0 1) click here for main article<\/a>\u00a0 2)\u00a0click here for shorter perspective summary<\/a>\u00a0 \u00a03)\u00a0homework on moodle<\/a><\/td>\n<\/tr>\n
\n

March\u00a030<\/strong><\/p>\n<\/td>\n

\n

Spring Break II – No Class<\/strong><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

April 2<\/strong><\/p>\n<\/td>\n

\n

EXAM III<\/strong><\/p>\n<\/td>\n

\u00a0exam covers from Feb 26th lecture on mammalian homeotic genes and stem cells – thru march 28th lecture on zebrafish neural crest and cancer.<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

April\u00a04<\/p>\n<\/td>\n

\n

Nervous system development – –\u00a0AXON GUIDANCE –\u00a0sildes<\/a><\/p>\n<\/td>\n

\n

Ch 15 – pp 488-515<\/p>\n<\/td>\n<\/tr>\n

\n

April\u00a06<\/p>\n<\/td>\n

Vertebrate limb development – slides pdf<\/a><\/td>\n\u00a0Chapter 19 –<\/p>\n

watch this dev bio tutorial before class<\/p>\n

https:\/\/sophia.smith.edu\/blog\/barresilab\/devidetorials\/#limbdevelopment<\/a><\/td>\n<\/tr>\n

\n

April\u00a09<\/p>\n<\/td>\n

\n

DEVELOPMENTAL MECHANISMS OF EVOLUTIONARY CHANGE – slides<\/a><\/p>\n<\/td>\n

\n

CH 26<\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

Note:<\/p>\n<\/td>\n

\n

Watch this video for homework and we will discuss on april<\/span> 10th -Kingsley video homework \u2013
\nhttps:\/\/www.youtube.com\/watch?v=PhjG19jgIKs<\/a><\/strong><\/p>\n

\n<\/td>\n

<\/td>\n<\/tr>\n
\n

April 11<\/p>\n<\/td>\n

Discuss: David Kingsley and three-spined
\nstickleback fish video lecture. slide capture images – pdf of slides<\/a><\/td>\n		<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
April 13<\/td>\nTeam 1 (Alzheimers\/stem cells)<\/p>\n

presentation slides –\u00a0here<\/a><\/p>\n

Team 2 (Darwin and Finch Beaks)<\/p>\n

powerpoint slides – here<\/a><\/td>\n

Team 1 –\u00a0Modeling familial Alzheimer’s disease with induced pluripotent stem cells<\/span><\/a><\/span><\/p>\n

Team 2 –\u00a0\u00a0A beak size locus in Darwin’s finches facilitated character displacement during a drought<\/a>.<\/td>\n<\/tr>\n

\u00a0April 16<\/td>\nTeam 3 (Developmental timing differences underlie armor loss across threespine stickleback) – presentation slides –\u00a0here<\/a><\/p>\n

Team 4 (DNA methylation signatures link prenatal famine exposure to growth) – presentation slides –\u00a0here<\/a><\/td>\n

\u00a0Team 3 –\u00a0Developmental timing differences underlie armor loss across threespine stickleback\u00a0Currey_et_al-2017-Evolution__Development<\/a><\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n
\u00a0Team 4 –\u00a0DNA methylation signatures link prenatal famine exposure to growth and metabolism<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n
April 18<\/p>\n

Undergraduate symposium – tell me if you are presenting a poster that day!!<\/td>\n

Team\u00a0 6 (Famine and epigenetics)<\/p>\n

slides –\u00a0here<\/a><\/td>\n

Team 6 –\u00a0Persistent epigenetic differences associated with<\/a>
\nprenatal exposure to famine in humans<\/td>\n<\/tr>\n
\n

April 20<\/p>\n<\/td>\n

Teams\u00a07 (Gene editing on human embryos)<\/p>\n

slides –\u00a0here<\/a><\/p>\n

Team 8 (Light-focusing human micro-lenses…)<\/p>\n

slides –\u00a0here<\/a><\/td>\n

Team 7 – Correction of a pathogenic mutation in human embryos<\/a><\/p>\n

Team 8 – Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro<\/a><\/td>\n<\/tr>\n

\n

April 23<\/p>\n<\/td>\n

Team 9 (twist and partners in human disease)<\/p>\n

slides –\u00a0here<\/a><\/td>\n

Team 9 –\u00a0\u00a0Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosi<\/a>s<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

April 25<\/p>\n<\/td>\n

\n

Reade Roberts – Guest lecturing – Evo. Devo in Cichlid fish<\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
April 27<\/td>\nreserve day<\/td>\n<\/td>\n<\/tr>\n
\n

MAY 4th<\/strong><\/p>\n<\/td>\n

\n

8 AM – Exam IV (AKA Final<\/strong>
\n Exam)\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Alternative is\u00a0 Discussion of Shh and cave fish evolution read paper by Jeffery group – powerpoint figures. Yamamoto and Jeffries paper to read click here<\/a>\u00a0 An interesting piece about the relevance of blind cave fish to human health. click here<\/a> for more details<\/p>\n","protected":false},"excerpt":{"rendered":"

Textbook: Developmental Biology by Scott Gilbert – 11th edition Instructor Dr. Robert Franks; Room 2548, Thomas Hall Email: rgfranks (at) ncsu.edu Phone: 513-7705 Office hours: by appointment January \u00a0 8 Introduction to Developmental Biology –\u00a001_08_18 Read Chapter 1 – hand in answer to one of these two questions – due Jan 10th\u00a0\u00a0first_day_discussion_questions.docx January \u00a0 10 […]<\/p>\n","protected":false},"author":277,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/users\/277"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":131,"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"predecessor-version":[{"id":303,"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/pages\/20\/revisions\/303"}],"wp:attachment":[{"href":"https:\/\/wordpress-projects.wolfware.ncsu.edu\/gn434v5-y3ct9jq\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}