Textbook: Developmental Biology by Scott Gilbert – 11th edition
Instructor Dr. Robert Franks; Room 2548, Thomas Hall
Email: rgfranks (at) ncsu.edu Phone: 513-7705
Office hours: by appointment
|
January 8 |
Introduction to Developmental Biology – 01_08_18 |
Read Chapter 1 – hand in answer to one of these two questions – due Jan 10th first_day_discussion_questions.docx |
|
|
January 10 |
In Class discussion of overview questions – 01_10_18 |
||
|
January 12 |
Developmental Anatomy, Fate mapping, Cell Lineage, medical embryology – 01_12_18v1 |
Chapter 1 |
|
|
January 15 |
MLK Holiday – no class Prep three questions or comments to hand in on Jan 17th related to Barresi Lab dev bio tutorial – USE MOODLE |
Prep for chapter 3 – Watch dev tutorial https://sophia.smith.edu/blog/barresilab/devidetorials/#differential-gene-expression |
|
|
Jan 17th |
SNOW DAY!! |
||
|
January 19 |
Discussion of Barresi Lab Dev Bio tutorial – 01_17_18v1 |
Chapter 3 |
|
|
January 22 |
Differential gene expression, parts of a gene, transcriptional regulation
|
Chapter 3 |
|
|
January 24 |
Differential gene expression, genetic screens, types of evidence |
Chapter 3 a good wikipedia page on histones covering additional details just FYI |
|
| January 26 |
Differential gene expression, genetic screens, types of evidence |
first monkeys cloned – news release this week | |
| Prep for chapter 4 – watch dev tutorial Prep three questions or comments to hand in on Jan 29th related to Barresi Lab dev bio tutorial USE MOODLE SITE |
watch dev tutorial on morphogen signaling
– https://sophia.smith.edu/blog/barresilab/devidetorials/#morphogen-signaling |
||
| January 29 | Differential gene expression – last lecture | Chapter 3 | |
|
Jan 31 |
Cell Signaling Paracrine factors 01_31_18 |
Chapter 4 |
|
|
Feb. 2 |
Extracellular matrix – induction – competence –02_02_18v3 |
Chapter 4 |
|
|
Feb. 5 |
EXAM I |
||
|
Feb 7. |
Plants and meristems 02_07_GN434_2018plantsv2 |
||
|
Feb. 9 |
Dr. Tim Kelliher, Syngenta Crop Protection – DEVBIOL_KELLIHER |
Haploid induction: Plants, Development and Biotechnology | |
|
Note: |
Choose paper to present in group presentation by Feb 16th | email me you favorite two topics/papers from list of topics | |
|
Watch drosophila introduction video click here for video – Prepare 3 questions or comments regarding this video to be turned in Feb. 12th. |
short bonus video on forward and reverse genetics in drosophlia | ||
|
Feb. 12 |
Drosophila part I – 02_12_18drosophila_I |
Ch 9 first half – a rather basic video on recombination mapping but good for review if you have forgotten |
|
|
Feb. 14 |
Drosophila |
Ch 9 |
|
|
Feb. 16 |
Drosophila |
Ch 9 |
|
|
Feb. 19 |
drosophila – discussion of original researcher paper – powerpoints from paper | Stathopoulous et al 2002 – click here for drosophila dorsal ventral paper | |
|
Feb 21 |
Drosophila part IIa |
Ch 9 second half |
|
|
Feb 23 |
Drosophila part III – 02_23_18 drosophilaIII |
Ch 9 second half | |
| prep for stem cell chapter watch dev bio tutorial – Prep three questions to hand in on Feb 26 | dev bio tutorial – https://sophia.smith.edu/blog/barresilab/devidetorials/#stem-cell-basics | ||
|
Feb 26 |
Mammalian homeotic and Stem Cells – 02_28_18 homeoticmouseandstemcells |
Chapter 5 |
|
|
Feb 28 |
Stem Cells |
Chapter 5 |
|
|
March 2 |
EXAM II | Link on Hox gene colinearity – why are hox genes organized on the chromosome as they are organized on the anterior posterior axis of the embryo? | |
|
March 5-9 spring break |
SPRING BREAK – NO CLASSES |
||
|
March 12 |
stem cells and ips cells 02_28_18_homeoticmouseandstemcellsv3 | Chapter 5 | |
|
March14 |
Amphibian Axis I powerpoint slides 03_14_18_amphibiansI |
Chapter 11 – up to p. 365
|
|
|
March 16 |
Discuss: Induction of Pluripotent Stem Cells – link to .ppt of slides 03_16_18_iPSymanakapaperv3 |
read Yamanaka research paper – click here to read iPS cells yamanaka and takahashi paper
|
|
|
March 19 |
Amphibian Axis II – 03_19_18amphibianspartsIIandIIIv3 |
Chapter 11 up to p365 | |
|
March 21 |
Amphibians finish up |
|
|
|
March 23 |
Guest Lecture – C. Elegans – Jim Mahaffey – Cell Death 2018 |
INTRO to C. elegans video – please watch before today’s class | |
| March 26 |
Neural Crest development CH15_neural crest |
Chapter 15 pp. 463-488 | |
|
March 28 |
Zebrafish neural crest and cancer – read and discuss the research paper |
1) click here for main article 2) click here for shorter perspective summary 3) homework on moodle | |
|
March 30 |
Spring Break II – No Class |
||
|
April 2 |
EXAM III |
exam covers from Feb 26th lecture on mammalian homeotic genes and stem cells – thru march 28th lecture on zebrafish neural crest and cancer. | |
|
April 4 |
Nervous system development – – AXON GUIDANCE – sildes |
Ch 15 – pp 488-515 |
|
|
April 6 |
Vertebrate limb development – slides pdf | Chapter 19 –
watch this dev bio tutorial before class https://sophia.smith.edu/blog/barresilab/devidetorials/#limbdevelopment |
|
|
April 9 |
DEVELOPMENTAL MECHANISMS OF EVOLUTIONARY CHANGE – slides |
CH 26 |
|
|
Note: |
|
||
|
April 11 |
Discuss: David Kingsley and three-spined stickleback fish video lecture. slide capture images – pdf of slides |
||
| April 13 | Team 1 (Alzheimers/stem cells)
presentation slides – here Team 2 (Darwin and Finch Beaks) powerpoint slides – here |
Team 1 – Modeling familial Alzheimer’s disease with induced pluripotent stem cells
Team 2 – A beak size locus in Darwin’s finches facilitated character displacement during a drought. |
|
| April 16 | Team 3 (Developmental timing differences underlie armor loss across threespine stickleback) – presentation slides – here
Team 4 (DNA methylation signatures link prenatal famine exposure to growth) – presentation slides – here |
Team 3 – Developmental timing differences underlie armor loss across threespine stickleback Currey_et_al-2017-Evolution__Development
|
|
| April 18
Undergraduate symposium – tell me if you are presenting a poster that day!! |
Team 6 (Famine and epigenetics)
slides – here |
Team 6 – Persistent epigenetic differences associated with prenatal exposure to famine in humans |
|
|
April 20 |
Teams 7 (Gene editing on human embryos)
slides – here Team 8 (Light-focusing human micro-lenses…) slides – here |
Team 7 – Correction of a pathogenic mutation in human embryos | |
|
April 23 |
Team 9 (twist and partners in human disease)
slides – here |
Team 9 – Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis | |
|
April 25 |
Reade Roberts – Guest lecturing – Evo. Devo in Cichlid fish |
||
| April 27 | reserve day | ||
|
MAY 4th |
8 AM – Exam IV (AKA Final
|
Alternative is Discussion of Shh and cave fish evolution read paper by Jeffery group – powerpoint figures. Yamamoto and Jeffries paper to read click here An interesting piece about the relevance of blind cave fish to human health. click here for more details